Tcel bonifed1/30/2024 The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. Constitutive pre-TCR signaling promotes differentiation through Ca2 + mobilization and activation of NF-κB and NFAT. This report establishes that pre-TCR activation of NF-κB is required to provide a survival signal for developing thymocytes to transition the DN3 checkpoint.Īifantis, I., Gounari, F., Scorrano, L., Borowski, C. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T cell development. NEMO/IKK gamma-deficient mice model incontinentia pigmenti. The role of nuclear factor-κB essential modulator (NEMO) in B cell development and survival. Kim, S., La Motte-Mohs, R.N., Rudolph, D., Zuniga-Pflucker, J.C. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. IκB kinase alpha is essential for mature B cell development and function. Non-canonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Regulatory T cells: mechanisms of differentiation and function. Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Transcriptional regulation in helper versus cytotoxic-lineage decision. Checkpoints in lymphocyte development and autoimmune disease. Signal strength in thymic selection and lineage commitment. Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. A positive look at double-negative thymocytes. Dissection of the NF-κB signalling cascade in transgenic and knockout mice. Functions of NF-κB1 and NF-κB2 in immune cell biology. Integrating cell-signalling pathways with NF-κB and IKK function. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Unraveling the complexities of the NF-κB signaling pathway using mouse knockout and transgenic models. IκB kinase complexes: gateways to NF-κB activation and transcription. The NF-κB family of transcription factors and its regulation. Transcriptional regulation via the NF-κB signaling module. Introduction to NF-κB: player, pathways, perspectives. Transcriptional drivers of the T-cell lineage program. Lymphoid development from stem cells and the common lymphocyte progenitors.
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